Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide

Inhibition of protein deacetylation enzymes, alone or in combination with standard chemotherapies, is an exciting addition to cancer therapy. We have investigated the effect of deacetylase inhibition on the metabolism of glioblastoma cells. 1H NMR metabolomics analysis was used to determine the majo...

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Detaylı Bibliyografya
Asıl Yazarlar: Miroslava Cuperlovic-Culf, Mohamed Touaibia, Patrick-Denis St-Coeur, Julie Poitras, Pier Morin, Adrian S. Culf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2014-09-01
Seri Bilgileri:Metabolites
Konular:
metaboloepigenomics
NMR metabolomics
glioblastoma
enzyme inhibitors
combined treatment
Online Erişim:http://www.mdpi.com/2218-1989/4/3/807
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