Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide

Inhibition of protein deacetylation enzymes, alone or in combination with standard chemotherapies, is an exciting addition to cancer therapy. We have investigated the effect of deacetylase inhibition on the metabolism of glioblastoma cells. 1H NMR metabolomics analysis was used to determine the majo...

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Detalhes bibliográficos
Main Authors: Miroslava Cuperlovic-Culf, Mohamed Touaibia, Patrick-Denis St-Coeur, Julie Poitras, Pier Morin, Adrian S. Culf
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2014-09-01
Colecção:Metabolites
Assuntos:
metaboloepigenomics
NMR metabolomics
glioblastoma
enzyme inhibitors
combined treatment
Acesso em linha:http://www.mdpi.com/2218-1989/4/3/807
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