Duloxetine, a Balanced Serotonin-Norepinephrine Reuptake Inhibitor, Improves Painful Chemotherapy-Induced Peripheral Neuropathy by Inhibiting Activation of p38 MAPK and NF-κB

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe, toxic side effect that frequently occurs in anticancer treatment and may result in discontinuation of treatment as well as a serious reduction in life quality. The CIPN incidence rate is as high as 85–90%. Unfortunately, there is current...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Jing Meng, Qiuyan Zhang, Chao Yang, Lu Xiao, Zhenzhen Xue, Jing Zhu
التنسيق: Artigo
اللغة:Inglês
منشور في: Frontiers Media S.A. 2019-04-01
سلاسل:Frontiers in Pharmacology
الموضوعات:
chemotherapy-induced peripheral neewopathy (CIPN)
duloxetine
oxaliplatin (OXA)
paclitaxel (PTX)
eripheral neuropathic pain
dorsal root ganglia (DRG)
الوصول للمادة أونلاين:https://www.frontiersin.org/article/10.3389/fphar.2019.00365/full
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