Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma

Abstract Background Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized treatment options in small bowel carcinoma. Methods We performed a DNA-...

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Detalhes bibliográficos
Main Authors: Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner, Sabine Merkelbach-Bruse
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-02-01
Colecção:BMC Gastroenterology
Assuntos:
Small bowel adenocarcinoma
BRCA mutation
PARP-inhibition
ERBB2 mutation
Microsatellite-instability
Acesso em linha:http://link.springer.com/article/10.1186/s12876-019-0942-z
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