High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter c...

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Autori principali: Sheng-Hai Zhang, Feng-Juan Gao, Zhong-Mou Sun, Ping Xu, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016-11-01
Serie:Frontiers in Cellular Neuroscience
Soggetti:
Hydrostatic Pressure
Mutation
Retinal Ganglion Cells
Mitochondrial dysfunction
mitochondrial DNA
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00254/full
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