High Pressure-Induced mtDNA Alterations in Retinal Ganglion Cells and Subsequent Apoptosis

Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter c...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Zhang, Sheng-Hai, Gao, Feng-Juan, Sun, Zhong-Mou, Xu, Ping, Chen, Jun-Yi, Sun, Xing-Huai, Wu, Ji-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121242/
https://ncbi.nlm.nih.gov/pubmed/27932951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00254
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