High pressure-induced mtDNA alterations in retinal ganglion cells and subsequent apoptosis

Purpose: Our previous study indicated that mitochondrial DNA (mtDNA) damage and mutations are crucial to the progressive loss of retinal ganglion cells (RGCs) in a glaucomatous rat model. In this study, we examined whether high pressure could directly cause mtDNA alterations and whether the latter c...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Sheng-Hai Zhang, Feng-Juan Gao, Zhong-Mou Sun, Ping Xu, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016-11-01
Edice:Frontiers in Cellular Neuroscience
Témata:
Hydrostatic Pressure
Mutation
Retinal Ganglion Cells
Mitochondrial dysfunction
mitochondrial DNA
On-line přístup:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00254/full
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky