Pharmacological blockade of either, cannabinoid CB1 or CB2 receptors, prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rats.

Addiction to major drugs of abuse such as cocaine has been recently linked to alterations on adult neurogenesis in the hippocampus. The endogenous cannabinoid system modulated this proliferative response since pharmacological activation/blockade of cannabinoid CB1 and CB2 receptors by modulating not...

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Main Authors: EDUARDO eBLANCO-CALVO, PATRICIA eRIVERA, SERGIO eARRABAL, ANTONIO eVARGAS, FRANCISCO JAVIER ePAVON, ANTONIA eSERRANO, PABLO eGALEANO, LETICIA eRUBIO, JUAN eSUAREZ, FERNANDO eRODRIGUEZ DE FONSECA
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-01-01
Colecção:Frontiers in Integrative Neuroscience
Assuntos:
Cocaine
Hippocampus
Neurogenesis
Rats
conditioning
cannabinoid receptors
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnint.2013.00106/full
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