Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer

Overwhelming evidence has shown the significant role of the tumor microenvironment (TME) in governing the triple-negative breast cancer (TNBC) progression. Digital pathology can provide key information about the spatial heterogeneity within the TME using image analysis and spatial statistics. These...

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Bibliographische Detailangaben
Hauptverfasser: Haoyang Mi, Chang Gong, Jeremias Sulam, Elana J. Fertig, Alexander S. Szalay, Elizabeth M. Jaffee, Vered Stearns, Leisha A. Emens, Ashley M. Cimino-Mathews, Aleksander S. Popel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020-10-01
Schriftenreihe:Frontiers in Physiology
Schlagworte:
digital pathology
image informatics
spatial patterns
breast cancer
tumor heterogeneity
immuno-architecture
Online Zugang:https://www.frontiersin.org/articles/10.3389/fphys.2020.583333/full
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