The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.

Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importance of glucose control. Glucokinase converts glucos...

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Main Authors: Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4032240?pdf=render
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