SLC4A4, FRAS1, and SULT1A1 Genetic Variations Associated With Dabigatran Metabolism in a Healthy Chinese Population

Background: The purpose of this study was to identify genetic variations associated with the metabolism of dabigatran in healthy Chinese subjects, with particular focus given to pharmacokinetics (PK) and pharmacodynamics (PD).Methods: Healthy Chinese adults aged 18–65 years with unknown genotypes fr...

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Detalhes bibliográficos
Main Authors: Qiufen Xie, Yuan Li, Zhiyan Liu, Guangyan Mu, Hanxu Zhang, Shuang Zhou, Zhe Wang, Zining Wang, Jie Jiang, Xin Li, Qian Xiang, Yimin Cui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Genetics
Assuntos:
dabigatran
genome-wide association analysis
candidate gene
wholeexome sequencing
pharmacokinetics
pharmacodynamics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2022.873031/full
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