Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists

The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of the innate responses to fight viral infection. The induction of the Janus kinase/signal transducer and activation of transcription (JAK/STAT) signalling pathway by IFNs leads to the upregulation of hundreds o...

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Autor principal: Stephen B. Fleming
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-06-01
Colecção:Vaccines
Assuntos:
interferon
viruses
immune evasion
JAK/STAT pathway
vaccines
innate immunity
Acesso em linha:http://www.mdpi.com/2076-393X/4/3/23
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