Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, and HR MS. Preliminary antitumor activity assay r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Long-fei Mao, Zhen-Zhen Wang, Qiong Wu, Xiaojie Chen, Jian-Xue Yang, Xin Wang, Yue-Ming Li
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2022-04-01
Sarja:Frontiers in Pharmacology
Aiheet:
erlotinib
EGFR
anticancer
drug-resistant cancer cell lines
1,2,3-triazole
Linkit:https://www.frontiersin.org/articles/10.3389/fphar.2022.849364/full
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