Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, and HR MS. Preliminary antitumor activity assay r...

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Main Authors: Long-fei Mao, Zhen-Zhen Wang, Qiong Wu, Xiaojie Chen, Jian-Xue Yang, Xin Wang, Yue-Ming Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Pharmacology
Assuntos:
erlotinib
EGFR
anticancer
drug-resistant cancer cell lines
1,2,3-triazole
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.849364/full
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