Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia–reperfusion injure by restoring CPT1A mediated fatty acid oxidation

Abstract Background Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it is not clear whether they can b...

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Detalhes bibliográficos
Main Authors: Zhumei Gao, Chuyue Zhang, Fei Peng, Qianqian Chen, Yinghua Zhao, Liangmei Chen, Xu Wang, Xiangmei Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
Colecção:Stem Cell Research & Therapy
Assuntos:
Mesenchymal stem cell
Hypoxic
Extracellular vesicles
Mitochondrial
Fatty acid oxidation
Renal fibrosis
Acesso em linha:https://doi.org/10.1186/s13287-022-02861-9
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