Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.

Dopaminergic nuclei in the basal ganglia are highly sensitive to damage from oxidative stress, inflammation, and environmental neurotoxins. Disruption of adenosine triphosphate (ATP)-dependent calcium (Ca2+) transients in astrocytes may represent an important target of such stressors that contribute...

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Main Authors: Karin M Streifel, Albert L Gonzales, Briana De Miranda, Rola Mouneimne, Scott Earley, Ronald Tjalkens
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4217743?pdf=render
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