A novel mouse model expressing human forms for complement receptors CR1 and CR2

Abstract Background The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer’s disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function of central components of the complement casca...

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Main Authors: Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-09-01
Series:BMC Genetics
Assuntos:
Complement cascade
Complement regulators
Immune cells
Alzheimer’s disease
Lupus
Hematopoietic cells
Acceso en liña:http://link.springer.com/article/10.1186/s12863-020-00893-9
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