Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats

<p>Abstract</p> <p>Background</p> <p>At present there is no effective and accepted therapy for hepatic fibrosis. Transforming growth factor (TGF)-β1 signaling pathway contributes greatly to hepatic fibrosis. Reducing TGF-β synthesis or inhibiting components of its compl...

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Bibliographic Details
Main Authors: Yao Qun-yan, Xu Bei-li, Wang Ji-yao, Liu Hong-chun, Zhang Shun-cai, Tu Chuan-tao
Format: Artigo
Language:Inglês
Published: BMC 2012-09-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Curcumin
Hepatic stellate cells
Liver fibrosis
Transforming growth factor-beta
Smads
Connective tissue growth factor
Online Access:http://www.biomedcentral.com/1472-6882/12/156
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