Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

Abstract Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Quanyi Zhao, Michael Dacre, Trieu Nguyen, Milos Pjanic, Boxiang Liu, Dharini Iyer, Paul Cheng, Robert Wirka, Juyong Brian Kim, Hunter B. Fraser, Thomas Quertermous
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BMC 2020-06-01
Σειρά:Genome Biology
Θέματα:
Coronary artery disease
Smooth muscle cells
Quantitative trait locus
TCF21
Chromosomal looping
Chromatin accessibility
Διαθέσιμο Online:http://link.springer.com/article/10.1186/s13059-020-02049-5
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