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How does a small molecule bind at a cryptic binding site?
Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to virtually all aspects of cellular function. Identifying small molecules that modulate specific disease-related PPIs is a strategy with enormous promise for drug discovery. The design of drugs to disrupt PPI...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2022-03-01
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| Colecção: | PLoS Computational Biology |
| Acesso em linha: | https://doi.org/10.1371/journal.pcbi.1009817 |
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