The Hyperpolarization-Activated Current Determines Synaptic Excitability, Calcium Activity and Specific Viability of Substantia Nigra Dopaminergic Neurons

Differential vulnerability between Substantia Nigra pars compacta (SNpc) and Ventral Tegmental Area (VTA) dopaminergic (DAergic) neurons is a hallmark of Parkinson’s disease (PD). Understanding the molecular bases of this key histopathological aspect would foster the development of much-needed disea...

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Main Authors: Carmen Carbone, Alessia Costa, Gustavo Provensi, Guido Mannaioni, Alessio Masi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-06-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
HCN channels
voltage-dependent calcium channels
patch clamp electrophysiology
excitotoxicity
Parkinson disease
differential vulnerability
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fncel.2017.00187/full
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