MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine

Abstract Background Methyl-CpG binding domain protein 1 (MBD1), which couples DNA methylation to transcriptional repression, has been implicated in transcriptional regulation, heterochromatin formation, genomic stability, cell cycle progression and development. It has also been proven that MBD1 is i...

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Detalhes bibliográficos
Main Authors: Liu Wensheng, Zhang Bo, Hu Qiangsheng, Xu Wenyan, Ji Shunrong, Xu Jin, Ni Quanxing, Yu Xianjun, Xu Xiaowu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-09-01
Colecção:Cancer Cell International
Assuntos:
Gallbladder cancer
Malignant behavior
Chemotherapeutic resistance
Methyl-CpG binding domain protein 1
Epithelial–mesenchymal transition
Acesso em linha:http://link.springer.com/article/10.1186/s12935-019-0948-1
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