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Lost by Transcription: Fork Failures, Elevated Expression, and Clinical Consequences Related to Deletions in Metastatic Colorectal Cancer

Among the structural variants observed in metastatic colorectal cancer (mCRC), deletions (DELs) show a size preference of ~10 kb–1 Mb and are often found in common fragile sites (CFSs). To gain more insight into the biology behind the occurrence of these specific DELs in mCRC, and their possible ass...

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Main Authors: Marcel Smid, Saskia M. Wilting, John W. M. Martens
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
Colecção:International Journal of Molecular Sciences
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Acesso em linha:https://www.mdpi.com/1422-0067/23/9/5080
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