Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.

Neuroendocrine prostate cancer is a lethal variant of prostate cancer that is associated with castrate-resistant growth, metastasis, and mortality. The tumor environment of neuroendocrine prostate cancer is heterogeneous and characterized by hypoxia, necrosis, and numerous mitoses. Although acidic e...

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Main Authors: Joseph E Ippolito, Matthew W Brandenburg, Xia Ge, Jan R Crowley, Kristopher M Kirmess, Avik Som, D Andre D'Avignon, Jeffrey M Arbeit, Samuel Achilefu, Kevin E Yarasheski, Jeffrey Milbrandt
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC4954648?pdf=render
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