Polymorphism 3435c> t of the ABCB1 gene (rs1045642) does not affect the mirtazapine efficiency and safety profile in patients with depressive disorders comorbid with alcohol use disorder

Background. Mirtazapine is used to treat patients with depressive disorders. A large proportion of patients in this group do not adequately respond to mirtazapine therapy, while many develop undesirable drug reactions of type A. According to the previous studies, P-gp is involved in the biotransform...

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Main Authors: M. S. Zastrozhin, E. A. Grishina, K. A. Ryzhikova, V. Yu. Skryabin, S. G. Koporov, E. A. Bryun, D. A. Sychev
Formato: Artigo
Idioma:Inglês
Publicado em: Siberian State Medical University (Tomsk) 2021-01-01
Colecção:Bûlleten' Sibirskoj Mediciny
Assuntos:
mirtazapine
abcb1
pharmacogenetics
biotransformation
personalized medicine
depressive disorder
alcohol use disorder
Acesso em linha:https://bulletin.tomsk.ru/jour/article/view/4152
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