The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Summary: Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in almost all cases of amyotrophic lateral sclerosis (ALS), and 20% of familial ALS cases are due to mutations in superoxide dismutase 1 (SOD1). Redox regulation is critical to maintain cellular homeostasis, although how...

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Bibliografiset tiedot
Päätekijät: Sonam Parakh, Sina Shadfar, Emma R. Perri, Audrey M.G. Ragagnin, Claudia V. Piattoni, Mariela B. Fogolín, Kristy C. Yuan, Hamideh Shahheydari, Emily K. Don, Collen J. Thomas, Yuning Hong, Marcelo A. Comini, Angela S. Laird, Damian M. Spencer, Julie D. Atkin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2020-05-01
Sarja:iScience
Aiheet:
Neurogenetics
Molecular Biology
Neuroscience
Linkit:http://www.sciencedirect.com/science/article/pii/S2589004220302820
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