Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidom...

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Main Authors: Jenifer Masip, Norma Rallón, Elena Yeregui, Montserrat Olona, Salvador Resino, José M. Benito, Consuelo Viladés, Graciano García-Pardo, José Alcamí, Ezequiel Ruiz-Mateos, Frederic Gómez-Bertomeu, Montserrat Vargas, Marta Navarro, José A. Oteo, Juan A. Pineda, Anna Martí, Verónica Alba, Francesc Vidal, Joaquin Peraire, Anna Rull
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
metabolomics
lipidomics
elite controllers (ECs)
HIV infection
Kreb's cycle
long-term
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.822272/full
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