Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice

Dysferlinopathies are muscle dystrophies caused by mutations in the gene encoding dysferlin, a relevant protein for membrane repair and trafficking. These diseases are untreatable, possibly due to the poor knowledge of relevant molecular targets. Previously, we have shown that human myofibers from p...

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Autori principali: Luis A. Cea, Gabriela Fernández, Guisselle Arias-Bravo, Mario Castillo-Ruiz, Rosalba Escamilla, María C. Brañes, Juan C. Sáez
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-08-01
Serie:International Journal of Molecular Sciences
Soggetti:
PPARγ
lipid accumulation
connexons
sarcolemma permeability
hemichannel blocker
creatine kinase
Accesso online:https://www.mdpi.com/1422-0067/21/17/6025
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