Evolution of PIKK family kinase inhibitors: A new age cancer therapeutics

Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, chromosome maintenance, DNA damage sensing and repair, cell cycle progressio...

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Detalhes bibliográficos
Main Authors: Althaf Shaik, Sivapriya Kirubakaran
Formato: Artigo
Idioma:Inglês
Publicado em: IMR Press 2020-03-01
Colecção:Frontiers in Bioscience-Landmark
Assuntos:
carcinoma
cancer
inhibitors
protein kinases
kinase domain
catalytic activity
phosphatidylinositol-3 kinase-related kinases
phosphatidylinositol 3-kinase
ataxia telangiectasia mutated kinase
atm- and rad3-related kinase
dna dependent protein kinase catalytic subunit
mammalian target of rapamycin (mtor)
smg: suppressor with morphological effect on genitalia family member (smg)
transformation/transcription-associated protein (traap)
quinolines
clinical trials
pharmacodynamics
pharmacokinetics
ic50
solubility
bioavailability
thiaanthrenpyran-4-one
rapalogs
pyrazine derivatives
pyrimidine derivatives
schisandrin
caffeine
wortmannin
auto phosphorylation
dfg motif
Acesso em linha:https://www.imrpress.com/journal/FBL/25/8/10.2741/4866
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