phydms: software for phylogenetic analyses informed by deep mutational scanning

It has recently become possible to experimentally measure the effects of all amino-acid point mutations to proteins using deep mutational scanning. These experimental measurements can inform site-specific phylogenetic substitution models of gene evolution in nature. Here we describe software that ef...

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Main Authors: Sarah K. Hilton, Michael B. Doud, Jesse D. Bloom
Format: Artigo
Sprog:Inglês
Udgivet: PeerJ Inc. 2017-07-01
Serier:PeerJ
Fag:
Deep mutational scanning
Phylogenetics
ExpCM
Codon substitution model
Diversifying selection
Positive selection
Online adgang:https://peerj.com/articles/3657.pdf
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