Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells

Background/Aims: Protodioscin (PD) is a steroidal saponin with anti-cancer effects on a number of cancer cells, but the anti-tumor effects and mechanism of action of PD on human cervical cancer cells is unclear. Methods: We determined cell viability using the MTT assay. Cell death, mitochondrial mem...

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Main Authors: Chia-Liang Lin, Chien-Hsing Lee, Chien-Min Chen, Chun-Wen Cheng, Pei-Ni Chen, Tsung-Ho Ying, Yi-Hsien Hsieh
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Colecção:Cellular Physiology and Biochemistry
Assuntos:
Protodioscin
Reactive oxygen species
Endoplasmic reticulum stress
Apoptosis
MAPK
Cervical cancer
Acesso em linha:https://www.karger.com/Article/FullText/488433
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