Synthesis of Novel Lipophilic N-Substituted Norcantharimide Derivatives and Evaluation of Their Anticancer Activities

This research attempted to study the effect of lipophilicity on the anticancer activity of N-substituted norcantharimide derivatives. Twenty-three compounds were synthesized and their cytotoxicities against five human cancer cell lines studied. The lipophilicity of each derivative was altered by its...

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Bibliographic Details
Main Authors: Jin-Yi Wu, Cheng-Deng Kuo, Chien-Yu Chu, Min-Shin Chen, Jia-Hua Lin, Yu-Jen Chen, Hui-Fen Liao
Format: Artigo
Language:Inglês
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
norcantharimide derivatives
lipophilic substitution
terpenyl group
anticancer activity
HepG2
apoptosis
Online Access:http://www.mdpi.com/1420-3049/19/6/6911
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