Synthesis of Novel Lipophilic N-Substituted Norcantharimide Derivatives and Evaluation of Their Anticancer Activities

This research attempted to study the effect of lipophilicity on the anticancer activity of N-substituted norcantharimide derivatives. Twenty-three compounds were synthesized and their cytotoxicities against five human cancer cell lines studied. The lipophilicity of each derivative was altered by its...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Jin-Yi Wu, Cheng-Deng Kuo, Chien-Yu Chu, Min-Shin Chen, Jia-Hua Lin, Yu-Jen Chen, Hui-Fen Liao
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2014-05-01
Sarja:Molecules
Aiheet:
norcantharimide derivatives
lipophilic substitution
terpenyl group
anticancer activity
HepG2
apoptosis
Linkit:http://www.mdpi.com/1420-3049/19/6/6911
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