Local iron deficiency in the substantia nigra directly contributes to hyperlocomotion phenotypes

Brain iron is precisely regulated, and disrupted brain iron homeostasis is implicated in neuropsychological disease. Mounting evidence connects the iron status of the substantia nigra (SN) with locomotion-related neural symptomatology. Researchers in this field have long speculated that iron deficie...

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Main Authors: Zhuo Wang, Yanjun Huang, Zhihua Zhou, Jian Huang, Yitong He, Pingming Qiu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-06-01
Colecção:Neurobiology of Disease
Assuntos:
Iron
Substantia nigra
Locomotion
Sleep
Transferrin receptor
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996122000857
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