Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies

Many therapeutic monoclonal antibodies (mAbs) were initially developed for intravenous (IV) administration. As a means to improve mAb drug-ability and the patient experience, subcutaneous (SC) administration is an increasingly important delivery route for mAbs. Unlike IV administration, bioavailabil...

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Autores principales: Amita Datta-Mannan, Selina Estwick, Chen Zhou, Hiuwan Choi, Nicole E. Douglass, Derrick R. Witcher, Jirong Lu, Catherine Beidler, Rohn Millican
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis Group 2020-01-01
Colección:mAbs
Materias:
Subcutaneous absorption
subcutaneous bioavailability
monoclonal antibody
physiochemical characterization
hydrophobicity
thermal stability
Acceso en línea:https://www.tandfonline.com/doi/10.1080/19420862.2020.1770028
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