Release of membrane-bound vesicles and inhibition of tumor cell adhesion by the peptide Neopetrosiamide A.

Neopetrosiamide A (NeoA) is a 28-amino acid tricyclic peptide originally isolated from a marine sponge as a tumor cell invasion inhibitor whose mechanism of action is unknown.We show that NeoA reversibly inhibits tumor cell adhesion, disassembles focal adhesions in pre-attached cells, and decreases...

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Main Authors: Pamela Austin, Markus Heller, David E Williams, Lawrence P McIntosh, A Wayne Vogl, Leonard J Foster, Raymond J Andersen, Michel Roberge, Calvin D Roskelley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-05-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2877099?pdf=render
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