Indoleamine-2,3-Dioxygenase in Thyroid Cancer Cells Suppresses Natural Killer Cell Function by Inhibiting NKG2D and NKp46 Expression via STAT Signaling Pathways

Natural killer (NK) cells are key players in the immune system. They use receptors on their cell surface to identify target cells. However, to escape being killed by the immune system, cancer cells such as thyroid cancer cells, use various methods to suppress the function of NK cells. Thus, this stu...

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Autors principals: Arum Park, Yunjeong Yang, Yunhee Lee, Mi Sun Kim, Young-Jun Park, Haiyoung Jung, Tae-Don Kim, Hee Gu Lee, Inpyo Choi, Suk Ran Yoon
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2019-06-01
Col·lecció:Journal of Clinical Medicine
Matèries:
NK cells
thyroid cancer cells
indoleamine 2,3-dioxygenase
kynurenine
NKG2D
NKp46
STAT1
STAT 3
Accés en línia:https://www.mdpi.com/2077-0383/8/6/842
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