Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Mast cells (MCs) are characterized by an abundance of lysosome-like secretory granules filled with immunomodulatory compounds including histamine, cytokines, lysosomal hydrolases, MC-restricted proteases, and serglycin proteoglycans. The latter are essential for promoting the storage of other granul...

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Detalhes bibliográficos
Main Authors: Jun Mei Hu Frisk, Lena Kjellén, Fabio R. Melo, Helena Öhrvik, Gunnar Pejler
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-07-01
Colecção:Frontiers in Immunology
Assuntos:
mast cells
mitogen-activated protein kinase
MEK1/2
proteoglycans
heparin
chondroitin sulfate
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01670/full
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