Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease

Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-<i>N</i>-[2-(2,3-dihydro-<i>1H<...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI AG 2019-01-01
श्रृंखला:International Journal of Molecular Sciences
विषय:
acetylcholinesterase inhibitors
Alzheimer’s disease
molecular modeling
beta amyloid
yeast three-hybrid technology (Y3H) test
ऑनलाइन पहुंच:https://www.mdpi.com/1422-0067/20/3/498
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