Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease

Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-N-[2-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamin...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Czarnecka, Kamila, Girek, Małgorzata, Kręcisz, Paweł, Skibiński, Robert, Łątka, Kamil, Jończyk, Jakub, Bajda, Marek, Kabziński, Jacek, Majsterek, Ireneusz, Szymczyk, Piotr, Szymański, Paweł
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386991/
https://ncbi.nlm.nih.gov/pubmed/30678364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030498
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