Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease

Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-<i>N</i>-[2-(2,3-dihydro-<i>1H<...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2019-01-01
Serie:International Journal of Molecular Sciences
Soggetti:
acetylcholinesterase inhibitors
Alzheimer’s disease
molecular modeling
beta amyloid
yeast three-hybrid technology (Y3H) test
Accesso online:https://www.mdpi.com/1422-0067/20/3/498
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi