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Substitution of Mannan-Binding Lectin (MBL)-Deficient Serum With Recombinant MBL Results in the Formation of New MBL/MBL-Associated Serine Protease Complexes

The lectin pathway (LP) of complement activation depends on the activation of the MBL-associated serine proteases (MASPs) circulating in complex with mannan-binding lectin (MBL). MBL deficiency is the most common complement deficiency and has been associated with several pathological conditions. As...

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Detalhes bibliográficos
Main Authors: Mischa P. Keizer, Angela Kamp, Gerard van Mierlo, Taco W. Kuijpers, Diana Wouters
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-06-01
Colecção:Frontiers in Immunology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01406/full
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