PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype

During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype. We have demonstrated that the inhibition of proprotein convertase 1/3 combined with TLR...

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Main Authors: Franck Rodet, Alice Capuz, Bilgehan-Aybike Ozcan, Rémy Le Beillan, Antonella Raffo-Romero, Firas Kobeissy, Marie Duhamel, Michel Salzet
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2019-11-01
Series:Cells
Assuntos:
anti-tumoral immunotherapy
macrophages
proprotein convertase 1/3
tlr4 desensitization
il-10 pro-tumoral effect
Acceso en liña:https://www.mdpi.com/2073-4409/8/12/1490
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