Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3

Summary: Sirtuin 3 (SIRT3) is a NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders. Here, we performed a small-molecule screen and identified an unexpected metabolic vulnerability a...

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Detalhes bibliográficos
Main Authors: Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018-02-01
Colecção:Cell Reports
Assuntos:
mitochondria
SIRT3
sirtuin
glutamine
nucleotide synthesis
mTORC1
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124718301402
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