ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells

Several reports have shown that a sciatic nerve conditioned media (CM) causes neuronal-like differentiation in PC12 cells. This differentiation is featured by neurite outgrowth, which are exclusively dendrites, without axon or sodium current induction. In previous studies, our group reported that th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Anna Sofia Trigos, Marines eLongart, Lisbeth eGarcia, Cecilia eCastillo, Patricia eForsyth, Rafael eMedina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2015-09-01
Cyfres:Frontiers in Cellular Neuroscience
Pynciau:
Axons
PC12 Cells
Sodium Channels
neuronal differentiation
sortilin
conditioned medium
Mynediad Ar-lein:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00364/full
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