ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells

Several reports have shown that a sciatic nerve conditioned media (CM) causes neuronal-like differentiation in PC12 cells. This differentiation is featured by neurite outgrowth, which are exclusively dendrites, without axon or sodium current induction. In previous studies, our group reported that th...

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Main Authors: Anna Sofia Trigos, Marines eLongart, Lisbeth eGarcia, Cecilia eCastillo, Patricia eForsyth, Rafael eMedina
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015-09-01
Serija:Frontiers in Cellular Neuroscience
Teme:
Axons
PC12 Cells
Sodium Channels
neuronal differentiation
sortilin
conditioned medium
Online dostop:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00364/full
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