PPAR-γ promotes p38 MAP kinase-mediated endothelial cell permeability through activating Sirt3

Abstract Background Ischemia-reperfusion (I/R)-induced vascular dysfunction is the main factor to acute ischemic stroke. Sirt3 is one of the sirtuin family members, which plays an important role in the development of neurological diseases. Methods In this study, we constructed I/R injury model on HB...

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Bibliografski detalji
Glavni autori: Zhenzhen Zhao, Xiaoxiu Zhang, Yuanqiang Dai, Ke Pan, Yu Deng, Yan Meng, Tao Xu
Format: Artigo
Jezik:Inglês
Izdano: BMC 2019-11-01
Serija:BMC Neurology
Teme:
PPAR-γ
p38
Sirt3
Cell permeability
Ischemia-reperfusion
Online pristup:http://link.springer.com/article/10.1186/s12883-019-1508-y
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