17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

Abstract Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endogenously generated from eicosapentaenoic acid that exhibi...

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Detalhes bibliográficos
Main Authors: Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Si‐Bum Park, Tetsuya Honda, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Prabha Tiwari, Eri Node, So‐ichiro Hirata, Koji Hosomi, Kenji Kabashima, Jun Ogawa, Jun Kunisawa
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2020-01-01
Colecção:FASEB BioAdvances
Assuntos:
anti‐inflammation
dermatitis
epoxy‐fatty acid
lipid mediators
structure‐activity relationship
Acesso em linha:https://doi.org/10.1096/fba.2019-00061
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