Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease

Background: Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynureni...

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Bibliographic Details
Main Authors: Harry R. Gosker, Gerard Clarke, Chiel C. de Theije, John F. Cryan, Annemie M. W. J. Schols
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
chronic obstructive pulmonary disease (COPD)
skeletal muscle
mental health
Online Access:https://www.mdpi.com/2077-0383/8/7/915
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