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Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation

INTRODUCTION: Physical inactivity significantly contributes to loss of muscle mass and performance in bed‐bound patients. Loss of skeletal muscle mitochondrial content has been well‐established in muscle unloading models, but the underlying molecular mechanism remains unclear. We hypothesized that a...

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Detalhes bibliográficos
Publicado no:Muscle Nerve
Main Authors: Leermakers, Pieter A., Kneppers, Anita E.M., Schols, Annemie M.W.J., Kelders, Marco C.J.M., de Theije, Chiel C., Verdijk, Lex B., van Loon, Luc J.C., Langen, Ramon C.J., Gosker, Harry R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900132/
https://ncbi.nlm.nih.gov/pubmed/31495926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.26702
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