β-Cyclodextrin and Oligoarginine Peptide-Based Dendrimer-Entrapped Gold Nanoparticles for Improving Drug Delivery to the Inner Ear

Here, we developed a safe and highly effective nanocarrier using β-cyclodextrin (β-CD) and oligoarginine peptide (Arg8)-modified dendrimer-entrapped gold nanoparticles (Au@CD-PAMAM-Arg8), with a diameter of 5 nm, for improved delivery of dexamethasone (Dex) to the inner ear. The properties and in vi...

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Main Authors: Jia Luo, XueXin Lin, LiLing Li, JingQian Tan, Peng Li
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-04-01
Serija:Frontiers in Bioengineering and Biotechnology
Teme:
drug delivery
dexamethasone
inner ear
spiral ganglion
outer hair cells
nerve fibers
Online dostop:https://www.frontiersin.org/articles/10.3389/fbioe.2022.844177/full
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